ABSTRACT
BACKGROUND: There are concerns regarding immunogenicity with coronavirus disease 2019 (COVID-19) mRNA vaccines among persons with prior history of COVID-19 (PHC). This study was to analyze the short-term side effects of mRNA vaccines among health care workers (HCWs) with and without PHC. METHODS: A cross-sectional study was performed using an independent online survey questionnaire that gathered responses from HCWs. RESULTS: Among 1,475 HCWs, 1268 (85.97%) completed the survey, 102/1268 (44/447 in Moderna group and 58/821 in Pfizer-BioNTech group) reported PHC during pre-vaccination period. Symptoms of flushing/P = .05, brain fogging/P= .005, vertigo/P= .041, numbness/P= .023, diarrhea/P= .047, hives/P= .028, itching/P= .028, swelling of lips/mouth/P= .001, shortness of breath/P= .022, and anxiety/P= .048 have greater occurrence among Pfizer-BioNtech group with PHC when compared to Pfizer-BioNtech group with no PHC. Symptoms of chills/P= .027, flushing/P= .045, tremor/P= .05, muscle spasm/P= .039, vomiting/P= .031, diarrhea/P= .015, and cough/P= .011 have higher occurrence among Moderna group with PHC when compared to Moderna group with no PHC. CONCLUSIONS: Few short-term side effects among mRNA vaccine recipients with PHC may have necessitated transient time-off from work. The PHC can be considered as a predictor for severity of side effects. While the vaccination program continues in the United States, a future COVID legislation that mandates vaccination among employees along with paid time off provision may help with higher compliance and acceptance.
Subject(s)
COVID-19 , mRNA Vaccines , Cross-Sectional Studies , Humans , SARS-CoV-2 , United States , Vaccines, SyntheticABSTRACT
The first cases were seen in Wuhan City of Hubei Province China in December 2019, and have been linked to the Huanan Seafood Market (South China) and the infection has spread to several countries around the world.4 The recombination of DNA was found to be involved at spike glycoprotein which assorted SARS- CoV (CoVZXC21 or CoVZC45) with the RBD of another Beta CoV, thus could be the reason for crossspecies transmission and rapid infection.5 The virus that causes coronavirus disease 19 (COVID-19) is a highly transmittable and pathogenic viral infection and mainly transmitted through contact with respiratory droplets rather than through the air. Higher-throughput It has become the preferred method.12 Average sensitivity for rapid molecular tests were 95.2% (ranging from 68% to 100%) and average specificity was 98.9% (ranging from 92% to 100%) between test results of different company brands and sampling methods15 Samples can be obtained by various methods, including a nasopharyngeal swab, sputum (coughed up material) throat swabs, deep airway material collected via suction catheter16 or saliva.
ABSTRACT
The virus outbreak has been declared a public health emergency of international concern by World Health Organization (WHO). M in the lipid bilayer is approximately 1:20:300.8 But human coronavirus NL63 is peculiar in that its M protein has the binding site for the host cell, and not its S protein.9 The spikes are the most distinguishing feature of coronaviruses, and are responsible for the corona- or halo-like surface. [121The virus that causes coronavirus disease 19 (COVID-19) is a highly transmittable and pathogenic viral infection and mainly transmitted through contact with respiratory droplets rather than through the air. According to the Wuhan University study, these are the symptoms of the patient that lead the patient to be admitted in the hospital.